Reaction of 2-Propynyl Acetate and 1,1-dimethyl-2-propynyl Chloroacetate with Amines

摘要

Polyfunctional acetylenic aminoesters exhibit a broad-spectum biological activity due to the precence of several receptor-binding centers [1,2] . To find the most active pharmacotropic fragments, we synthesized a series of new complex acetylenic aminoesters which are also intersting synthons for further transformations. We established that the aminoesters are most convenient to prepare by reactions of 2-propynyl acetates and 1,1-dimethyl-2-propynyl chloroacetate with amines.