Investigation of the effect of photosensitizer Tiosense on the tumor model mel Kor-TurboRFP expressed red fluorescent protein

摘要

The work is devoted to the study of the action of photosensitizer Thiosens on the fluorescent tumor model mel Kor-TurboRFP. It was shown that cell line mel Kor-TurboRFP is sensitive to the phototoxic action of Thiosens in vitro. That allows to use of fluorescent tumor mel Kor-TurboRFP to study the photodynamic action of Thiosens in vivo. Non-invasive monitoring of fluorescence of tumor mel Kor-TurboRFP sensitized by Thiosens allows independent control of the dynamics of the three-dimensional distribution of the fluorescent tumor and the photosensitizer. This makes it possible to optimize the PDT approach, allowing the most optimal way to choose the time to start of tumor irradiation, irradiation time and the irradiated area patterns.