Synthesis of Aryl Substituted Quinones as beta-Secretase Inhibitors: Ligand-Free Direct Arylation of Quinones with Aryl Halides

摘要

The simple ligand-free direct arylation of quinones with aryl halides applying Pd(OAc)(2) as a catalyst in accordance with Heck reaction was studied. This reaction provided a simple and efficient synthetic approach to efficient inhibitors of beta-secretase aryl-substituted quinones.