Synthesis of N-Aminoglycosides on the Basis of the d-Pseudoephedrine Alkaloid

摘要

N-Glycosylation of many amino compounds,including natural physiologically active amines,is considered as a new approach to creation of versatile drugs of preset action due to effective transport of carbohydrate fragments [1-4].Introduction of carbohydrate fragments to the structure of physiologically active compounds not only increases their water solubility,but also decreases their toxicity,which allows glycosylation of a physiologically active compound(or some of its fragments)at the glycoside carbohydrate center as one of the possible methods for preparing low-toxicity drugs [5].