Oxidation of ascorbic acid in the presence of phthalocyanine metal complexes. Chemical aspects of catalytic anticancer therapy. 1. Catalysis of oxidation by cobalt octacarboxyphthalocyanine

摘要

The kinetics of oxidation of ascorbic acid in the presence of cobalt octa-4,5-carboxy-phthalocyanine sodium salt (Teraphthal) was studied. A kinetic euation was obtained and a scheme of the proces was proposed. According to the scheme, the first stage is the formation of a complex of the catalyst with dioxygen, and the limiting stage is the reaction of dioxygen with the ascorbate monoanion. The influence of the pH of the medium and the presence of a transport protein (albumin) on the state and catalytic activity of Teraphthal was studied. The involvement of hydrogen peroxide and oxygen-centered adicals in the catalytic osidation of ascorbic acid was proved.