Impracticality of egg donor recruitment in the absence of compensation.

摘要

Unfertilized oocytes of many mammalian species can reprogram somatic cells to a pluripotent state. Human oocytes might therefore be useful for producing patient-derived pluripotent stem cells. Because they would carry the patient's genotype, these stem cells may be useful for the production of autologous transplants. Such cells could also be used to determine whether the epigenetic (Lister et al., 2011) and genetic (Gore et al., 2011) changes detected in induced pluripotent stem cells (iPSCs) are universally found in reprogrammed cell lines or instead are unique to iPSCs. In addition to their importance for the study of re-programming and nuclear transplantation, human oocytes have significant utility for research aimed at the establishment of new infertility treatments. Therefore, there is ample scientific rationale for the use of oocytes in research.