Risk Factors for Gallstone Disease in Patients with Gallstones Having GallstoneHeredity. A Case-Control Study

摘要

Method. Plasma levels of HDL-cholesterol, triglycerides, cholesterol and glycaemia were assessed in 109 patients with gallstones having at least one affected sibling (females/males=95/14, age 54.36+-11.22 yrs, BMI 29.06+-5.36 kg/m2) and in 271 controls without gallstones (females/males=248/23, age 52.82+-10.94 yrs, BMI 26.00+-4.63 kg/m2). Student's t test, Mann-Whitney test and chi square test were used to compare BMI, plasma lipid levels, prevalence of diabetes mellitus and pregnancies.Results. Patients with gallstone disease had higher BMI (p=0.0000005) as compared to controls. Plasma triglyceride levels were significantly higher and serum HDL-cholesterol levels significantly lower in patients than in controls (p=0.00001, respectively, p=0.0002). Basal glycaemia was also significantly higher in patients than in controls (p=0.00006). The prevalence of diabetes mellitus was significantly higher in cases than in controls (p=0.00001). In univariate logistic regression analysis, BMI, triglycerides, low HDL-cholesterol, increased glycaemia and diabetes mellitus were significantly associated with gallstone disease, but in multiple logistic regression analysis, only BMI had a significant effect.Conclusion. The main risk factor for gallstone disease in cases with known heredity of gallstone disease is BMI.