Comparison of surface cooling and invasive cooling for rapid induction of mild therapeutic hypothermia in pigs--effectiveness of two different devices.

摘要

AIM OF THE STUDY: The effectiveness and safety of non-invasive surface cooling was compared to invasive endovascular cooling in an animal model. METHODS: Eight healthy pigs (29-38 kg) were cooled twice, starting in the first 4 pigs with unique surface cooling pads followed by endovascular cooling. In the second 4 pigs the order was reversed. The goal was to quickly lower pulmonary artery temperature from 38 to 33 degrees C. A paired t-test was used to compare cooling rates ( degrees C/h, mean+/-standard deviation) between both cooling techniques. RESULTS: Mean non-invasive surface cooling rate (11.9+/-3.8 degrees C/h) significantly exceeded mean invasive cooling rate (3.9+/-0.7 degrees C/h; p<0.001). The mean difference in cooling rates was 8.0+/-3.6 degrees C/h. No surface cooling related adverse skin reactions were observed. CONCLUSIONS: Surface cooling is a simple method for achieving fast cooling rates. In our animal model, non-invasive cooling was three times faster than rapid endovascular cooling without overshoot.