Lipoxins: update and impactof endogenous pro-resolution lepid mediators

摘要

Lipoxins (LXs) are endogenously produced eicosanoids that are typically generated by transcellular biosynthesis,. These trihydroxytetraene-containing lipid mediators and their stable synthetic analogues possess a wide spectrum of anti-inflammatory and pro-resolution bioactions both in vitro and in vivo. More recently, LXs have emerged as potential anti-fibrotic mediators that may influence pro-fibrotic cytokines and matrix-associated gene expression in response to platelet-derived growth factor (PDGF), Here we review the biosynthesis, metabolism and bioactions of LXs and LX analogues and their therapeutic potential.