Monitoring of Radionuclide Impurities in ~(166)Ho-Albumin Microspheres Prepared by Neutron Activation with Thermal Neutrons

摘要

Analysis of radionuclide impurities in ~(166)Ho-albumin microspheres prepared by activation with thermal neutrons of ~(165)Ho preliminarily incorporated in the particle matrix was performed. The content of impurities in the final product was determined by gamma-ray spectroscopy. With ~(166)Ho-albumin microspheres as example, an algorithm was developed for evaluation of the radiochemical purity of the preparation. It was found that the radiochemical purity of the preparation, which is primarily determined by impurities of rareearth elements, can be estimated from the content of ~(152m)Eu.