Hydrogels synthesised through photoinitiator-free photopolymerisation technique for delivering drugs including a umour-tracing porphyrin

摘要

Hydrogels were synthesised using the photoinitiator-free photopolymerisation technique involving interactions between donor/acceptor pairs for delivering drugs of different molecular weights including a porphyrin used as a tumour-tracing agent.N-(5-hydroxy) pentylmaleimide,an acceptor,formed hydrogels with N-vinyl-2-pyrrolidinone,2-hydroxyethyl methacrylate and N-vinylcaprolactum.Glucosamine,an effective H-donor in enhancing polymerisation as shown by Differential Photocalorimetric results,was found unsuitable for hydrogel preparation.Drugs of different molecular weights releasing at the same rate was discussed.The hydrogels were found to have no toxic effects and were biocompatible with a human keratinocyte cell line.