Nano-manganese hydrogen sulfate as a novel catalyst for the anti-diastereoselective Mannich reaction in water

摘要

beta-Amino carbonyl compounds are attractive targets for chemical synthesis, because they are widely used as biologically active compounds and are important synthons for a variety of pharmaceuticals. Nano-manganese hydrogen sulfate was prepared and used as a novel nano-catalyst for the named organic transformation, i.e. Mannich-type reaction of benzaldehyde, aniline, and cyclohexanone in water. Mannich products were obtained in high yields, with excellent diastereoselectivity, and short reaction time in the presence of a catalytic system comprising nano-Mn(HSO4)(2) and a surfactant, for example sodium dodecyl sulfate. Use of mild, environmentally benign reaction conditions, low loading, and ready accessibility are the main features of this new catalyst.