Most biomolecular and cell surface sensing strategies use specific interactions between antibodies and target analytes, e.g., ELISA and antibody arrays. Sensory processes such as taste and smell, however, use differential binding where the receptors interact with their analytes by selective rather then specific binding events. Applying this approach to sensors, a.k.a. "chemical noses," provides a potentially powerful alternative to traditional immu-nosensor methods. In the "nose" approach, an array of different receptors is generated, with the individual elements of the array responding to a range of different analytes. The distinct response pattern generated from the array then provides a fingerprint for classification and/or identification of the target.
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