Liver regeneration and energetic changes in rats following hepatic radiation therapy and hepatocyte transplantation by P-31 MRSI

摘要

Background & AimsRadiation-induced liver damage (RILD) is a poorly understood and potentially devastating complication of hepatic radiation therapy (RT) for liver cancers. Previous work has demonstrated that hepatocyte transplantation (HT) can ameliorate RILD in rats. We hypothesized that RT inhibits generation of cellular ATP and suppresses hepatic regeneration.