Pharmacokinetics of the individual enantiomer S-(+)-ketoprofen after intravenous and oral administration in dogs at two dose levels

摘要

The pharmacokinetic of the individual S-(+)-enantiomer of ketoprofen, S-(+)-ketoprofen, after intravenous (IV) and oral (PO) administration was determined in six dogs at 1 and 3 mg/kg. Plasma concentrations were determined by high performance liquid chromatography with ultraviolet detection. The concentration-time curves were analyzed by non-compartmental methods. Steady-state volume of distribution (Vss) and clearance (Cl) of S-(+)-ketoprofen after IV administration were 0.22 +/- 0.07 and 0.19 +/- 0.03 L/kg, and 0.10 +/- 0.02 and 0.09 +/- 0.01 L/h/kg, at 1 and 3 mg/kg, respectively. Following PO administration, S-(+)-ketoprofen achieved maximum plasma concentrations of 4.91 +/- 0.76 and 12.47 +/- 0.6211g/ ml, at two dose levels, respectively. The absolute bioavailability after PO route was 88.66 +/- 12.95% and 85.36 +/- 13.90%, respectively