Aconitine, a Main Component of Aconite, Increases Spontaneous Acetylcholine Release from the Frontal Cerebral Cortex of Freely Moving Rats

摘要

We investigated whether peripherally administered aconitine increases spontaneous acetylcholine (ACh) release from the frontal cerebral cortex in freely moving rats using in vivo microdialysis, as it relates to aconitine-induced bradycardia estimated by a tail-artery cuff technique in unilateral anterior hypothalamus (AH)-lesion mice. Intraperitoneally administered aconitine significantly increased cortical ACh release within 15 min at 10 and 30 /Jg/kg. The increasing effect disappeared 30 min after the administration of aconitine. Aconitine-induced ACh release was not inhibited by intraccrebroventricularly preadministered atropine (1 and 3 /ig/rat). Atropine (1 /(g/mouse) preadministered into the contralateral intact AH in mice did not affect aconitine (30 /