Fused deposition modeling of patient-specific polymethylmethacrylate implants

摘要

Purpose - The purpose of this paper is to investigate the use of medical-grade polymethylmethacrylate (PMMA) in fused deposition modeling (FDM) to fabricate porous customized freeform structures for several applications including craniofacial reconstruction and orthopaedic spacers. It also aims to examine the effects of different fabrication conditions on porosity and mechanical properties of PMMA samples. Design/methodology/approach - The building parameters and procedures to properly and consistently extrude PMMA filament in FDM for building 3D structures were determined. Two experiments were performed that examined the effects of different fabrication conditions, including tip wipe frequency, layer orientation, and air gap (AG) (or distance between filament edges) on the mechanical properties and porosity of the fabricated structures. The samples were characterized through optical micrographs, and measurements of weight and dimensions of the samples were used to calculate porosity. The yield strength, strain, and modulus of elasticity of the samples were determined through compressive testing. Findings - Results show that both the tip wipe frequency (one wipe every layer or one wipe every ten layers) and layer orientation (transverse or axial with respect to the applied compressive load) used to fabricate the scaffolds have effects on the mechanical properties and resulting porosity. The samples fabricate in the transverse orientation with the high tip wipe frequency have a larger compressive strength and modulus than the lower tip wipe frequency samples (compressive strength: 16±0.97 vs 13±0.71 MPa, modulus: 370±14 vs 313±29 MPa, for the high vs low tip wipe frequency, respectively). Also, the samples fabricated in the transverse orientation have a larger compressive strength and modulus than the ones fabricated in the axial orientation (compressive strength: 16±0.97 vs 13±0.83 MPa, modulus: 370±14 vs 281±22 MPa; for samples fabricated with one tip wipe per layer in the transverse and axial orientations, respectively). In general, the stiffness and yield strength decreased when the porosity increased (compressive strength: 12±0.71 to 7±0.95 MPa, Modulus: 248±10 to 165±16 MPa, for samples with a porosity ranging from 55 to 70 percent). As a demonstration, FDM is successfully used to fabricate patient-specific, 3D PMMA implants with varying densities, including cranial defect repair and femur models. Originality/value - This paper demonstrates that customized, 3D, biocompatible PMMA structures with varying porosities can be designed and directly fabricated using FDM. By enabling the use of PMMA in FDM, medical implants such as custom craniofacial implants can be directly fabricated from medical imaging data improving the current state of PMMA use in medicine.