Ksenia Guseva: Formation and Cooperative Behavior of Protein Complexes on the Cell Membrane Doctoral thesis from Institute of Complex System and Mathematical Biology of the University of Aberdeen, UK, Springer, ISBN 978-3-642-23987-8

摘要

The thesis as a book on formation and cooperative behavior of protein complexes on the cell membrane highlights three major sections on protein oligomerization on cell surface, review approaches on membrane protein oligomerization and validation of oligomer formation process mainly using pure physical/theoretical models. These chapters cover an existing knowledge on membrane protein oligomer formation, experimental approaches with focus on mechanosensitive channels, interactions in oligomer assembly/stability, protein fragmentation, and pore formation in Tat complex system. In almost every chapter, physical/theoretical models have been integrated. A merger of protein oligomerization phenomena and theoretical physics is not quite intriguing for biologists/biochemists lacking adequate knowledge in physical modeling and its theoretical applications, and vice versa.