The decapping scavenger enzyme DCS-1: A new modulator of miRNA turnover

摘要

MicroRNAs are small non-coding RNA able to silence posttranscriptionally gene expression of targeted mRNAs through partial base-pairing interactions. Found in nearly all eukaryotes (with the notable exception of yeast), microRNA-mediated gene regulation is involved in almost all biological processes. In recent years, many studies have described a correlation between changes in microRNA levels and several human pathologies. Different mechanisms have been proposed to control expression and maturation of microRNAs, and a number of cellular factors have been implicated in the regulation of microRNA biogenesis mainly by modulating activity of the processing complexes.