HYDROGENATION OF METHYL 3alpha-ACETOXY-23-OXO-5beta-CHOLAN-24-OATE CATALYZED BY CINCHONA ALKALOID-MODIFIED Pt-ALUMINA CATALYST

摘要

Methyl-3alpha-acetoxy-23-oxo-5beta-cholan-24-oate is hydrogenated with 78% enantioselection at C23 atom over Pt-alumina catalyst modified with cinchona alkaloids,in liquid phase under mild experimental conditions (293-297 K,hydrogen pressure: 1 bar,concentration of modifiers: 0.1 mmol/L,solvent: THF).