Safety and effectiveness of medication and aspiration abortion before or during the sixth week of pregnancy: A retrospective multicenter study

摘要

abstract_textpObjective: To compare adverse outcomes of medication and aspiration abortion among those with intrauterine pregnancy 43 days gestation versus abortions performed at 43-48 days./ppStudy design: We conducted a multicenter retrospective chart review study to review all medication and aspiration abortion of visualized pregnancy 49 days gestation at Planned Parenthood Columbia Willamette (Oregon) and Planned Parenthood of Orange and San Bernardino Counties (California) in 2014-2015. We identified incident cases by billing codes and performed chart review for adverse outcomes (ED visits, incomplete abortion), need for further interventions, or complications (hemorrhage, infection, and uterine perforation), captured up to 90 days post-abortion./ppResults: The 3930 abortions during the study period at the two sites included 2914 medication abortions and 1016 aspiration abortions, with 1470 medication abortions and 469 aspiration abortions at 43 days gestation. Composite adverse outcomes did not vary by gestation, for either medication abortion (75/1470; 5.1 for 43 days versus 94/1444; 6.5 at 43-48 days, p = 0.10) or aspiration (12/469; 2.6 for 43 days versus 16/547; 2.9 at 43-48 days, p = 0.72). Fewer incomplete abortions (ongoing pregnancy, symptomatic retained tissue, or retained gestational sac) occurred in the earlier gestational group (3.1 for 43 days versus 4.3 at 43-48 days, p = 0.04). Composite adverse outcomes were higher after medication versus aspiration abortion (169/2914; 5.8 versus 28/1016; 2.7, p 0.01)./ppConclusion: Medication and aspiration abortion performed either before or during the sixth week of ultrasound-confirmed intrauterine pregnancy have low rates of composite adverse outcomes, including complications or incomplete abortion. However, unplanned interventions are more common after medication compared to aspiration abortions. (C) 2020 Elsevier Inc. All rights reserved./p/abstract_text