Preparation of F-18-NHC-BF3 conjugates and their applications in PET imaging

摘要

N-Heterocyclic carbene boron trifluoride (NHC-BF3) conjugates were successfully radiofluorinated by SnCl4-promoted F-18-F-19 isotopic exchange reaction in one labelling step. This method afforded in vivo stable PET agents that efficiently bound to targeted tumours yielding PET images with good tumour-to-background contrast.