Irisin in Coronary Bypass Surgery

摘要

Introduction: In coronary bypass surgery, after cardiopulmonary bypass is initiated byarterial cannulation in the ascending aorta and venous cannulation through a single vein generally inthe right atrium, the process of cooling the patient is started.Objective: There is a relation between cooling the patient and irisin, which is responsible for releasingheat. Therefore, the main objective of the present study is to explore how irisin concentrationsand some other panel of myocardium injury in patients undergoing coronary artery bypass surgery.Methods: The blood samples collected before induction (T1), before bypass (T2), before (T3) andafter (T4) removing the cross-clamp, upon admission to intensive care (T5), and at the postoperative24 (T6) and 72 (T7) hours, and whether these concentrations are correlated with lactatelevels classically used in monitoring this surgery. A total of biological samples, 23 from controlindividuals and 105 from bypass patients (14-16 samples for each timeframe) were analyzed todetermine irisin, CK-MB, TnT and BNP levels by ELISA and lactate levels by lactate assay kit.Both lactate and irisin were seen to increase gradually from the time of induction to the removal ofthe cross-clamp. After the cross-clamp was removed and the patient was started to be warmed, bothparameters began to decrease gradually and were restored to normal levels on the second and thirdpost-operative days. The increase and decrease in irisin were found correlated with lactate levels.CK-MB, TnT and BNP alteration were similar to each other.Results: Based on these results, it is estimated that measurement of irisin along with lactate mayprove to be a useful parameter in monitoring the coronary bypass surgery and irisin may be a significantmarker of hypothermia. Beside CK-MB, TnT and BNP, measurements of irisin concentrationin open heart surgery may also be useful parameters for the panel of myocardium injury.