DNA-damaged polyploid cancer cells can reverse to diploidy: an ordered, but little understood, process of genomic reduction (with reference to the previous comments of Forer (2008) and Wheatley (2008a and b)).

摘要

When cancer cells are exposed to DNA damaging agents at doses that are insufficient to induce apoptosis, such as those used in chemotherapy or radiotherapy, they frequently become polyploid in the days following treatment. Polyploidy is the result of the process called endoreplication or endor-eduplication (Storchova and Pellman, 2004). DNA-damaged cancer cells stop proliferating by circumventing normal mitosis while undergoing repeated cycles of DNA synthesis, leading first to the G2 phase of the cell cycle, then to various grades of polyploidy.