ZrOCl_2 centre dot 8H_2O as an environmentally friendly and recyclable catalyst for the chemoselective synthesis of 2-aryloxazolines and bis-oxazolines under thermal conditions and microwave irradiation

摘要

The reactions of arylnitriles with(3-aminoalcohols to prepare 2-aryloxazolines has been efficiently carried out in the presence of catalytic amounts of ZrOCl_2 centre dot 8H_2O using heat or microwave irradiation.Synthesis of mono-and bis-oxazolines from dicyanobenzenes was accomplished with high selectivity using this catalyst.Chemoselective conversion of arylnitriles to their corresponding 2-oxazolines in the presence of alkylnitriles was also achieved by this method.The use of ZrOCl_2 centre dot 8H_2O catalyst is feasible because of its easy availability,easy handling,stability,easy recovery,reusability,good activity and eco-friendly.