An integrated microsystem for injection,transport and manipulation of encoded microbeads on a single microchip is presented.The device also incorporates a customized reaction chamber to process individual,optically encoded microbeads.This research illustrates how microfabrication technologies enable convenient integration of multiple capabilities of microbeads,controlled microfluidic injection,integration of heater elements and temperature sensors and detection of microbeads in a single microfluidic chip.A practical application for the integrated microsystem is confirmed by the ability to select a specific DNA sequence of interest from a 4 x 4 cDNA library.This application emphasizes the advantages of component integration for rapid bio-assay development in a complete microsystem.
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机译：提出了一种用于在单个微芯片上注射，传输和操纵编码微珠的集成微系统。该设备还集成了定制的反应室，可以处理单个光学编码的微珠。这项研究说明了微制造技术如何实现多种微珠功能的便捷集成，控制微流体注射，在单个微流体芯片中集成加热器元件和温度传感器以及检测微珠。通过从4 x 4 cDNA文库中选择感兴趣的特定DNA序列的能力，证实了集成微系统的实际应用。本申请强调了组件集成在完整的微系统中快速进行生物测定开发的优势。
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