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Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction

机译:骨髓脂肪组织是一种内分泌器官,在热量限制期间有助于增加循环脂联素

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摘要

Summary The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for this paradox remain unclear. Unlike white adipose tissue (WAT), bone marrow adipose tissue (MAT) increases during CR, and both MAT and serum adiponectin increase in many other clinical conditions. Thus, we investigated whether MAT contributes to circulating adiponectin. We find that adiponectin secretion is greater from MAT than WAT. Notably, specific inhibition of MAT formation in mice results in decreased circulating adiponectin during CR despite unaltered adiponectin expression in WAT. Inhibiting MAT formation also alters skeletal muscle adaptation to CR, suggesting that MAT exerts systemic effects. Finally, we reveal that both MAT and serum adiponectin increase during cancer therapy in humans. These observations identify MAT as an endocrine organ that contributes significantly to increased serum adiponectin during CR and perhaps in other adverse states.
机译:总结脂肪细胞源性脂联素可促进代谢和心血管健康。循环脂联素在瘦身状态(例如热量限制(CR))下会增加,但这种矛盾的原因仍不清楚。与白色脂肪组织(WAT)不同,CR期间骨髓脂肪组织(MAT)增加,在许多其他临床情况下,MAT和血清脂联素均增加。因此,我们调查了MAT是否有助于循环脂联素。我们发现,脂联素从MAT的分泌大于WAT。值得注意的是,尽管在WAT中脂联素的表达未发生改变,但在小鼠中对MAT形成的特异性抑制导致循环脂联素减少。抑制MAT的形成也会改变骨骼肌对CR的适应性,提示MAT发挥全身作用。最后,我们揭示了人类癌症治疗期间MAT和血清脂联素均增加。这些观察结果确定MAT是内分泌器官,在CR期间以及其他不良状态下可显着促进血清脂联素的增加。

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