Preparation of cyclotron-produced Re-186 and comparison with reactor-produced Re-186 and generator-produced Re-188 for the labeling of bombesin

摘要

The radioisotopes Re-186 and Re-188 have been extensively investigated for various forms of radiotherapy due to their useful and high-abundance particle emissions, low-abundance and imageable gamma-rays, and chemical resemblance to technetium. In addition. Re-188 is available in no-carrier-added (NCA) form from long lived W-188 generators, whereas Re-186 can be produced in large quantities from reactors, although not in NCA form. However NCA Re-186 can be produced on a cyclotron by a (p,n) reaction on W-186. The purpose of this Study was to compare labeling of the peptide bombesin with these three forms of rhenium radioisotopes.