SYNTHESIS OF 1,2,3,4,5,7-HEXAHYDRO-6H-AZOCINO4,3-bINDOL-6-ONES AS INTERMEDIATES FOR THE SYNTHESIS OF APPARICINE

摘要

1-Phenylsulfonylindole is converted in eight steps into 2-(2-iodo-(Z)-but-2-en-1-yl)-6-methyl-1,2,3,4-tetrahydroazocino4,3-bindole, previously converted in one step into the indole alkaloid apparicine. The syntheses of other hexahydroazocino4,3-bindole potential precursors to the alkaloid are also described.