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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Dorsal striatum and stimulus-response learning: lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning.
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Dorsal striatum and stimulus-response learning: lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning.

机译:背侧纹状体和刺激反应学习:背侧纹状体,而不是背体纹状体病变,损害了基于刺激反应的仪器识别任务的获取,同时保留了条件性位置偏爱学习。

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摘要

While some evidence suggests that the dorsal striatum is important for stimulus-response learning, disagreement exists about the relative contribution of the dorsolateral and dorsomedial striatum to this form of learning. In the present experiment, the effects of lesions of the dorsolateral and dorsomedial striatum were investigated on two tasks that differentially require the development of stimulus-response learning. The first task utilized an operant conditional discrimination task, which is likely to rely heavily upon stimulus-response learning. The second task looked conditioned place preference learning, a task that is unlikely to require the development of stimulus-response associations. Animals with lesions of the dorsolateral striatum were impaired on the operant conditional discrimination task, but retained the ability to learn the conditioned place preference task. In contrast, animals with lesions of the dorsomedial striatum were not found to be impaired on either task used in the present experiment. These results suggest that the dorsolateral striatum is necessary for the successful acquisition of tasks that place a demand upon stimulus-response learning, while the dorsomedial striatum is not involved in this type of learning.
机译:虽然一些证据表明背侧纹状体对于刺激反应学习很重要,但关于背外侧纹和背侧纹状体对这种学习形式的相对贡献存在分歧。在本实验中,对背外侧和背侧纹状体的损伤的影响在两个任务上进行了研究,这些任务有区别地需要刺激反应学习的发展。第一项任务利用了操作性条件歧视任务,该任务很可能严重依赖于刺激响应学习。第二项任务看起来是有条件的位置偏好学习,这是一项不太可能需要发展刺激反应协会的任务。患有背外侧纹状体损伤的动物在操作性条件歧视任务中受损,但保留了学习条件性位置偏爱任务的能力。相反,在本实验中使用的任一项任务均未发现患有背纹状体损伤的动物。这些结果表明,背侧纹状体对于成功完成对刺激响应学习有要求的任务是必要的,而背侧纹状体不参与这种类型的学习。

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