Drastic photochemical stabilization of lomefloxacin through selective and efficient self-incorporation of its cationic form in anionic sodium dodecyl sulfate (SDS) micelles

摘要

It is shown that a 30-fold photochemical stabilization of the highly photoreactive and photocarcinogenic fluoroquinolone lomefloxacin can be achieved through a selective and efficient sequestering of its cationic form by a suitable micellar system at neutral pH.