Structural Organization of Striatal Microgliocytes after Transient Focal Ischemia

摘要

Microgliocytes are known not to be structurally stable cellular elements; altering the lengths of their processes, they control the synaptic organization of the brain. The aim of the present work was to study the structural organization of the microglia in the striatum and periventricular area of the telencephalon of the rat after transient focal ischemia. Ischemic lesions without cerebral infarction were found to lead to activation of the microglia, promoting reorganization of the striatal neuropil. Activation of microgliocytes was associated with changes in their shape, from the characteristic dendritic shape to the oval and round shapes typical of the ameboid microglia. Microgliocytes were able to proliferate after ischemia.