Lipid peroxidation and cancer

摘要

Lipoxidation is formed during the oxidation of lipids and specific proteins, causing analteration in proteins function. Although this occurs under physiological conditions, in manycases, it has been associated with pathological processes, including cancer. Oxidative DNAdamage is a significant contributor to cancer development, and lipoxidation products such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) play a role in the induction of mutations responsible for DNA modifications. Elevations of reactive aldehydes can be seen inpatients with metastatic disease in comparison to those without metastatic disease. Lipoxidation adducts can modify the immune response, consequently causing either positive or negative alterations in cancer progression. When reactive aldehydes are added totumor cells, they exert similar effects to chemotherapeutic drugs by forming DNA adducts andconsequently steer the tumor cells toward apoptosis. This article highlights the role ofbotanical compounds in lipid metabolism, lipid peroxidation, and cell cycle arrest anddiscusses the potential role they may have in oncology treatments.