Glucuronidation of serine and threonine

摘要

The synthesis of N-diphenylmethylene-O-(methyl(2,3,4-triO-acetyl)-beta-D-glucuronosyl)-th reonine benzyl ester (2) and N-diphenylmethylene-O-(methyl(2,3,4-tri-O-acetyl)-alpha/beta-D-glucurono syl)-serine benzyl ester (3) by Hanessian's modification of the Koenigs-Knorr reaction is presented. Highly nucleophilic benzophenone Schiff bases are used for the protection of the N-moiety of serine and threonine.