Thermal studies, structural characterization, and antimicrobial evaluation of coordinated metal complexes containing salen moiety

摘要

Using the bidentate ligand N,N'-bis(2-methoxy-benzylidene)ethylenediamine salen Schiff base, Cu(II), Cr(III), and La(III) complexes were prepared and structurally characterized using several physicochemical techniques. The thermal behavior of the synthesized complexes was investigated using simultaneous thermogravimetry (TG) and differential thermal analysis (DTA) techniques. The geometrical configurations of the complexes are proposed to be octahedral. Antimicrobial and antifungal activities of the reported complexes were tested and evaluated in vitro using modified Kirby-Bauer disc diffusion and minimum inhibitory concentration methods. The prepared complexes show remarkable antimicrobial activity; in particular, the Cr(III) complex exhibits potential inhibition against Escherichia coli, Staphylococcus aureus, and Candida albicans. On the other hand, the lanthanum complex presents higher in vitro antimicrobial activity when compared with the copper complex. In vitro antimicrobial activity assays indicate that the novel complexes might serve as promising candidates for new therapeutic agents.