Synthesis of rimonabant regioisomer

摘要

A novel synthesis route for a rimonabant regioisomer was developed. Impurities' profiling of active pharmaceutical ingredients (APIs) imposes a great challenge in pharmaceutical industries and a renaissance for the same is now seen as an indispensable aspect of drugs and their process development for the following reasons: i) to assure that the elicited pharmacological or tox-icological effects are only due to the API and not due to impurities, ii) also to ensure that in the due course of the product formulation and marketing the impurities should not be generated or elevated, and iii) impurities can not be considered always to be inferior, it may have better pharmacological and inferior toxicological properties.