Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

摘要

A series of twelve 5-trihalomethyl-3-aryl-isoxazoles was synthesized and screened for antibacterial and antifungal activities.The compounds were synthesized from the cyclondensation of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones[CX3C(O)C(R2)=C(R1)OR,where X=Cl and F;R=Me;R2=H;R1=H,Me,F,Cl,Br,and NO2]with hydroxylamine hydrochloride through a rapid one-pot reaction via microwave irradiation.Some of the 5-trihalomethyl-3-arylisoxazoles exhibited good in vitro snti-Cryptococcus activity.