Asymetric Allylic Substitution Reactions with a Xylophos-Pd Catalyst

摘要

The chiral diphosphine ligand xylophos (1) was tested as an auxiliary in palladium catalyzed allylic substitution reactions. Whereas its activity was found to be generally good only in the case of 1,3-diphenylprop-2-en-1-yl acetate, a fair level of asymetri cinduction was achieved with odium dimethyl malonate (83% ee) and benzylamine (66% ee) as nucleophiles.