首页> 外文期刊>Neurology India. >Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy.
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Dual pathology of corticobasal degeneration and Parkinson's disease in a patient with clinical features of progressive supranuclear palsy.

机译:具有进行性核上性麻痹临床特征的患者的皮质基底皮质变性和帕金森氏病的双重病理学。

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摘要

Corticobasal degeneration and Parkinson's disease are pathologically distinct disorders with unique histological and biochemical features of a tauopathy and a-synucleinopathy respectively. We report the first case of co-occurrence of these pathologies in the same patient. Convergence of such distinctly separate neuropathology in the same brain highlights the need for extensive brain banking and further research in supporting the hypothesis that tauopathies and a-synucleinopathies might share common pathogenic mechanisms.
机译:肾上腺皮质变性和帕金森氏病是病理学上不同的疾病,分别具有τ蛋白病和α-突触核蛋白病的独特组织学和生化特征。我们报告了在同一患者中同时出现这些病理的第一例。在同一大脑中,这种截然不同的神经病理学的融合凸显了需要广泛的大脑储备,并需要进一步的研究来支持假说和α-突触核蛋白病可能共享共同的致病机制的假说。

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