Do we understand how botulinum toxin works and have we optimized the way it is administered to the bladder? ICI-RS 2014

摘要

AimsThe use of botulinum toxin A (BoNT/A) is commonplace now in the management of refractory overactive bladder and neurogenic detrusor overactivity (NDO). Despite one formulation now having a license, the full mechanism of action is not fully understood. Furthermore practice varies worldwide in the way the toxin is delivered to the bladder. At the ICI-RS 2014 Meeting in Bristol, UK a Think Tank session was conducted on the topic of Do we understand how botulinum toxin works and have we optimized the way it is administered to the bladder? This manuscript reflects the Think Tank's summary and opinion.