Recent Progress in T-reg Biology and Transplant Therapeutics

摘要

Purpose of Review Regulatory T cell (T-reg) biology continues to evolve at a rapid pace. The role of T-regs in solid organ transplantation offers a unique window into T-reg ontogeny and function as well as limitless possibilities for clinical application. Here we review recent significant discoveries and key translational work. Recent Findings Advances in transplantation deepen understanding of T-reg differentiation, expansion, transcription, co-stimulation, and signaling. T cell receptor (TCR) sequencing and single-cell analytics allow unprecedented insight into T-reg repertoire diversity and phenotypic heterogeneity. Efforts to replace conventional immunosuppression with T-reg adoptive immunotherapy are underway and coalescing around strategies to increase efficiency through development of donor-reactive T-regs. Adoptive immunotherapy with T-regs is a leading tolerogenic strategy. Early clinical trials suggest that T-reg infusion is safe and reports on efficacy will soon follow.