Stroke. a new window of opportunity for stroke rehabilitation?

摘要

Modulation of neuroplasticity in the region surrounding an infarct could provide the key to functional recovery after stroke, research published in Nature reveals. In a mouse stroke model, Tom Carmichael and his colleagues at the University of California, Los Angeles demonstrated increased gamma-aminobutyric acid (GABA)-mediated tonic inhibition in the peri-infarct zone, and showed that an inverse agonist of extrasynaptic GABA_A receptors could promote recovery of motor function in the animals.