A new gamma-lactone from the leaves of Cinnamomum kotoense.

摘要

A new C19 gamma-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC50 values ranged from 3.3 +/- 0.3 to 25.8 +/- 5.3 microM.