In a study published in the European Journal of Neurology, Graff-Radford et al. retrospectively reviewed the medical records of patients identified as having Othello syndrome-a condition associated with severe delusional jealousy-and investigated the clinical and imaging features in these individuals. The authors have advanced current knowledge of delusional disorders by quantitatively examining neuroimaging features of this specific group of patients. The researchers used the Mayo Clinic medical records linkage and indexing system to retrospectively identify patients with possible Othello syndrome, probing the database using additional search terms including "delusions and infidelity" and "delusions of infidelity or jealousy". Their success highlights the importance of using detailed clinical databases for studying rare clinical phenomena-perhaps those who are not so meticulous should be jealous!
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