Disease mechanisms in MS: Informing tactics to combat MS

摘要

The precise cause of MS and the immunological targets remain obscure, and the clinical course is highly heterogeneous between patients. Moreover, relapsing-remitting MS (RRMS)—the most common form of the disease —involves alternating periods of clinical worsening and abatement, commonly followed by sustained deterioration during secondary progressive MS (SPMS). Each of these stages involves numerous disease mechanisms and, as such, MS represents a multifaceted adversary. On the other hand, endogenous neuroreparative and functional recovery mechanisms are activated during remission, highlighting an area where "knowing oneself" could provide clues to inform therapeutic strategies.