Immunostaining findings in IgA nephropathy: Correlation with histology and clinical outcome in the Oxford Classification patient cohort

摘要

I have read with interest the article by Bellur et al. [1] published recently in your premier journal. It describes the im-munohistological findings of IgA nephropathy (IgAN) and their correlation with the clinical and histological features of this disease at the time of renal biopsy and the final renal outcome. The study cohort used for this study is the same as that used for the development of original Oxford Classification of IgAN. The study may be considered as an important adjunct to the original Oxford Classification of IgAN, which was entirely based on the pathological evaluation of morphological features [2, 3]. It is worth mentioning here that soon after its publication, some investigators raised the point of lack of immunofiuorescence (IF) or electron microscopic (EM) findings in the original classification and their correlation, if any, with the morphological and clinical features at the time of diagnosis and the final outcome [4].