Sodium citrate anticoagulation during sustained low efficiency dialysis (SLED) in patients with acute renal failure and severely impaired liver function

摘要

Due to severe side effects, sodium citrate anticoagulation has been avoided in patients with severely impaired liver function undergoing renal replacement therapy [1]. Based on a previously published protocol, seven patients with acute renal failure (diagnosed according to accepted guidelines) and severely impaired liver function (mean Child-Pugh score: 10.5 +- 0.5) received a total of 10 sustained low efficiency dialysis (SLED) treatments using the Genius dialysis system [2-4]. For this study, a high-flux membrane (FX 50, Fresenius Medical Care, Bad Homburg, Germany) was used. The dialysate contained 1.0 mmol/L calcium, 30 mmol/L bicarbonate and 135 mmol/L (n = 9) or 138 mmol/L (n = 1) sodium.