Synapsin II desynchronizes neurotransmitterrelease at inhibitory synapses by interactingwith presynaptic calcium channels

摘要

In the central nervous system, most synapses show a fast mode of neurotransmitter releaseknown as synchronous release followed by a phase of asynchronous release, which extendsover tens of milliseconds to seconds. Synapsin II (SYN2) is a member of the multigenesynapsin family (SYN1/2/3) of synaptic vesicle phosphoproteins that modulate synaptictransmission and plasticity, and are mutated in epileptic patients. Here we report that inhibitorysynapses of the dentate gyrus of Syn II knockout mice display an upregulation ofsynchronous neurotransmitter release and a concomitant loss of delayed asynchronousrelease. Syn II promotes g-aminobutyric acid asynchronous release in a Ca2+-dependentmanner by a functional interaction with presynaptic Ca2+ channels, revealing a new role insynaptic transmission for synapsins.