(-)-Sclerotiorin from an Unidentified Marine Fungus as an Anti-meiotic and Anti-fungal Agent

摘要

(-)-Sclerotiorin, Isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0 50 mu M (-)-Sclerotiorin also showed antifungal activity against Saccharomyces cerevisiae, Aspergilus fumigatus, Alternaria longipes, Piricularia oryzae, Verticillium albo-atrum, Fusarium culmorum, and F nivale with IC50 values less than 20 mu g/mL