Increased trafficking

摘要

Genome-wide array-based comparative genome hybridization analysis of 83 human melanoma samples has revealed a focal amplification at 5p13, which was also frequently found in other solid tumours, such as colon adenocarcinoma and non-small-cell lung carcinoma (NSCLC). Further analyses by Lynda Chin and colleagues have identified GOLPH3 as an oncogene encoded in this region.